A well-written and insightful article. I find most interesting the coniguity of science research to the cause and perhaps prevention of aging, as aging is an inevitable part of life.
Of course diet and exercise plays a huge role in health and longevity, but i wonder how calorie restriction should be utilized in order to prevent mTOR. Is CR just a scientific term for prevention of obesity/being over-weight?
Something else to note, the FDA doesnt approve/test a large majority of supplements being sold to consumers. It's important to obtain supplements such as taurine and resveratrol from trusted sources so as not to be spending money on vegetable capsules filled with empty calories.
One final thought, for the conspiracy theorists... There is a population crisis on Earth, most notably in the Asian continent. Immigration from Asia/Middle East has swept over the world. Would longer lifespans speed up the over population of Earth? Furthermore, life longevity would not look desire-able to the people who run the world (whether they be billionaires or lizard people - depending on the conspirator). How would the US government, secret organizations, or 'lizard people' hinder the research and preventions of aging? There are already conspiracies towards Bill Gates' "Apeel" program (chemical coating over fruits and veggies) with supposed eugenic properties.
CR is more than avoiding obesity. Certainly, going from obese to normal weight extends longevity. There are physiological changes (anti-aging) going further in calorie reduction. Not that I am recommending CR- it is really a a question of why does this work?
I always seek supplements from a US lab that employs cGMP - good advice.
Thanks for the feedback on the ITP tests of resveratrol. I'll look into the papers claiming positive results to try to discern differences in protocol.
I am not aware of any ITP proposal for Taurine - the paper is so new (June) and I doubt the authors would have submitted am proposal to ITP prior to the publishing date
It says: "Coincidentally, Singh et al. (2023) recently reported that supplementation of taurine (a different amino acid) increased median lifespan of treated mice by over 10%, although such an effect is largely novel and the study was only performed in the highly inbred C57BL/6 strain. Unfortunately, taurine has not yet been tested in the ITP. [...] In the case of taurine, there is but a single, unreplicated study, claiming an almost implausibly high effect size and what is, frankly, almost an excessively clean narrative of anti-aging effects in the absence of much background literature."
A well-written and insightful article. I find most interesting the coniguity of science research to the cause and perhaps prevention of aging, as aging is an inevitable part of life.
Of course diet and exercise plays a huge role in health and longevity, but i wonder how calorie restriction should be utilized in order to prevent mTOR. Is CR just a scientific term for prevention of obesity/being over-weight?
Something else to note, the FDA doesnt approve/test a large majority of supplements being sold to consumers. It's important to obtain supplements such as taurine and resveratrol from trusted sources so as not to be spending money on vegetable capsules filled with empty calories.
One final thought, for the conspiracy theorists... There is a population crisis on Earth, most notably in the Asian continent. Immigration from Asia/Middle East has swept over the world. Would longer lifespans speed up the over population of Earth? Furthermore, life longevity would not look desire-able to the people who run the world (whether they be billionaires or lizard people - depending on the conspirator). How would the US government, secret organizations, or 'lizard people' hinder the research and preventions of aging? There are already conspiracies towards Bill Gates' "Apeel" program (chemical coating over fruits and veggies) with supposed eugenic properties.
CR is more than avoiding obesity. Certainly, going from obese to normal weight extends longevity. There are physiological changes (anti-aging) going further in calorie reduction. Not that I am recommending CR- it is really a a question of why does this work?
I always seek supplements from a US lab that employs cGMP - good advice.
Lizard people? not my area
Thanks for this excellent article!
Resveratrol was tested 3 times in the NIH Interventions Testing Program (ITP) and failed to show any benefit on lifespan (contrary to acarbose, rapamycin and a few others): https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions
Do you know by any chance if someone has already submitted a proposal to test taurine in the ITP? (See: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/application-instructions ) Anyone can request a test so I may well do it...
Thanks for the feedback on the ITP tests of resveratrol. I'll look into the papers claiming positive results to try to discern differences in protocol.
I am not aware of any ITP proposal for Taurine - the paper is so new (June) and I doubt the authors would have submitted am proposal to ITP prior to the publishing date
I've just read this article that you may like: https://milkyeggs.com/biology/lifespan-extension-separating-fact-from-fiction/
It says: "Coincidentally, Singh et al. (2023) recently reported that supplementation of taurine (a different amino acid) increased median lifespan of treated mice by over 10%, although such an effect is largely novel and the study was only performed in the highly inbred C57BL/6 strain. Unfortunately, taurine has not yet been tested in the ITP. [...] In the case of taurine, there is but a single, unreplicated study, claiming an almost implausibly high effect size and what is, frankly, almost an excessively clean narrative of anti-aging effects in the absence of much background literature."
Excellent article Dr. Coleman.